1. Ivachtchenko A.V., Dmitriev D.E., Golovina E.S., Dubrovskaya E.S., Kadieva M.G., Koryakova A.G., Kysil V.M., Mitkin O.D., Tkachenko S.E., Okun I.M., Vorobiov A.A. Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT(6) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 2010 Feb 14. in press.

2. Kysil V., Khvat A., Tsirulnikov S., Tkachenko S, Williams C., Churakova M., Ivachtchenko A. General Multicomponent Strategy for the Synthesis of 2-Amino-1,4-diazaheterocycles: Scope, Limitations, and Utility. European Journal of Organic Chemistry. 2010; 1525-1543.

3. Ivachtchenko A., Golovina E., Kadieva M., Koryakova A., Kovalenko S., Mitkin O., Okun I., Ravnyeyko I., Tkachenko S., Zaremba O. Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines – Selective Serotonin 5-HT(6) Receptor Antagonists. Journal of Combinatorial Chemistry. 2010; in press.

4. Ivachtchenko A.V., Mitkin O.D., Tkachenko S.E., Okun I.M., Kysil V.M. 8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT(6) receptor antagonists. European Journal of Medicinal Chemistry. 2010; 45(2): 782-789.

5. Ivachtchenko A.V., Frolov E.B., Mitkin O.D., Tkachenko S.E., Okun I.M., Khvat A.V. Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles. Bioorganic & Medicinal Chemistry Letters. 2010; 20(1): 78-82.

6. Okun I., Tkachenko S.E., Khvat A., Mitkin O., Kazey V., Ivachtchenko V.A. From Anti-allergic to Anti-Alzheimer’s: Molecular Pharmacology of Dimebon. Current Alzheimer Research. 2009 Nov 26. [Epub ahead of print].

7. Ivachtchenko A.V., Frolov E.B., Mitkin O.D., Kysil V.M., Khvat A.V., Tkachenko S.E. Synthesis and Biological Evaluation of Novel 5,8-Disubstituted-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b] indoles as 5-HT(6) and H(1) Receptors Antagonists. Archiv der Pharmazie (Weinheim). 2009; 342(12):740-747.

8. Tkachenko S., Ivachtchenko A., Okun I., Lavrovsky Y., Mitkin O., Salimov R. P4-212: Comparision of highly selective and non-selective 5-HT6 receptor antagonists in in vitro and in vivo neurodegenerative models. Alzheimer’s and Dementia. 2009; 4(4); Supplement 1: P492.

9. Ivachtchenko A.V., Frolov E.B., Mitkin O.D., Kysil V.M., Khvat A.V., Okun I.M., Tkachenko S.E. Synthesis and biological evaluation of novel γ-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 2009; 19(12): 3183-3187.

10. Kysil V.M., Khvat A., Tsirulnikov S., Tkachenko S., Ivachtchenko A. Multicomponent approach to unique 1,4-diazepine-2-amines. Tetrahedron Letters. 2009; 50(24): 2854-2856.

11. Balakin KV, Ivanenkov YA, Savchuk NP. Compound library design for target families. Methods Molecular Biology. 2009; 575: 21-46.

12. Ivanenkov YA, Savchuk NP, Ekins S, Balakin KV. Computational mapping tools for drug discovery. Drug Discovery Today. 2009; 14(15-16): 767-75.
13. Bushkova E, Parchinsky V, Krasavin M. Efficient entry into hydrazinopeptide-like structures via sequential Ugi reactions. Molecular Diversity. 2009 Nov 10. [Epub ahead of print]

14. Krasavin M, Karapetian R, Konstantinov I, Gezentsvey Y, Bukhryakov K, Godovykh E, Soldatkina O, Lavrovsky Y, Sosnov AV, Gakh AA. Discovery and potency optimization of 2-amino-5-arylmethyl-1,3-thiazole derivatives as potential therapeutic agents for prostate cancer. Archiv der Pharmazie (Weinheim). 2009; 342(7): 420-7.

15. Krasavin M, Shkavrov S, Parchinsky V, Bukhryakov K. Imidazo[1,2-a]quinoxalines accessed via two sequential isocyanide-based multicomponent reactions. Journal of Organic Chemistry. 2009; 74(6): 2627-9.

16. Salimov R., Tkachenko S. P1-019: Effect of Tacrine and Dimebon on scopolamine- and dizocipline-induced memory impairment in mice. Alzheimer’s and Dementia. 2008; 4(4); Supplement 1: T211.

17. Tkachenko S.E. P2-478: Discovery and in vivo evaluation of potent 5-HT6 receptor antagonists for cognition enhancement in treating Alzheimer’s disease. Alzheimer’s and Dementia. 2008; 4(4); Supplement 1: T514.

18. Sandulenko Yu.B., Ivashchenko A.V., Kravchenko D.V., Tkachenko S.E., Vvedensky V.Yu. Parallel solid-phase synthesis of novel 3,7-diazabicyclo[3.3.1]nonane derivatives starting from natural alkaloid cytisine. Russian Chemical Bulletin. 2008; 57(9): 1999-2004.

19. Ivanenkov Y.A., Balakin K.V., Tkachenko S.E. New approaches to the treatment of inflammatory disease: focus on small-molecule inhibitors of signal transduction pathways. Drugs in R&D. 2008; 9(6): 397-434.

20. Balakin K.V., Ivanenkov Y.A., Tkachenko S.E., Kiselyov A.S., Ivachtchenko A.V. Regulators of chemokine receptor activity as promising anticancer therapeutics. Current Cancer Drug Targets. 2008; 8(4): 299-34.

21. Okun I., Balakin K.V., Tkachenko S.E., Ivachtchenko A.V. Caspase activity modulators as anticancer agents. Anti-Cancer Agents in Medicinal Chemistry. 2008; 8(3): 322-341.

22. Lavrovsky Y, Ivanenkov YA, Balakin KV, Medvedeva DA, Ivachtchenko AV. CXCR4 receptor as a promising target for oncolytic drugs. Mini Reviews in Medicinal Chemistry.  2008; 8(11): 1075-87.

23. Chekmarev DS, Kholodovych V, Balakin KV, Ivanenkov Y, Ekins S, Welsh WJ. Shape signatures: new descriptors for predicting cardiotoxicity in silico. Chemical Research in Toxicology. 2008; 21(6): 1304-14.

24. Koryakova AG, Ivanenkov YA, Ryzhova EA, Bulanova EA, Karapetian RN, Mikitas OV, Katrukha EA, Kazey VI, Okun I, Kravchenko DV, Lavrovsky YV, Korzinov OM, Ivachtchenko AV. Novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamides as selective GSK-3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008; 18(12): 3661-6.

25. Ivachtchenko A.V.; Kiselyov A.S.; Tkachenko S.E.; Ivanenkov Y.A.; Balakin K.V. Novel Mitotic Targets and Their Small-Molecule Inhibitors. Current Cancer Drug Targets. 2007; 7(8): 766-784.

26. Balakin K.V., Ivanenkov Y.A., Kiselyov A.S., Tkachenko S.E. Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anti-Cancer Agents in Medicinal Chemistry. 2007; 7(5): 576-92.

27. Kysil V., Tkachenko S., Khvat A., Williams C., Tsirulnikov S., Churakova M., Ivachtchenko A. TMSCl-Promoted Isocyanide-Based MCR of Ethylenediamines: an Efficient Assembling of 2-Aminopyrazine Core. Tetrahedron Letters, 2007; 48(36): 6239-6244.

28. Kiselyov A.S., Tkachenko S.E., Balakin K.V., Ivachtchenko A.V. Small-molecule modulators of Hh and Wnt signaling pathways. Expert Opinion on Therapeutic Targets. 2007; 11(8): 1087-1101.

29. Kiselyov A.S., Balakin K.V., Tkachenko S.E., Savchuk N.P., Ivachtchenko A.V. Recent Progress in Discovery of Antimitotic Agent. Anti-Cancer Agents in Medicinal Chemistry. 2007; 7: 189-208.

30. Ilyin AP, Dmitrieva IG, Kustova VA, Manaev AV, Ivachtchenko AV. Synthesis of heterocyclic compounds possessing the 4H-thieno[3,2-b]pyrrole moiety. Journal of Combinatorial Chemistry. 2007; 9(1): 96-106.

31. Balakin K.V., Tkachenko S.E., Kiselyov A.S., Savchuk N.P. Focused chemistry from annotated libraries. Drug Discovery Today: Technologies. 2006; 3(4): 397-403.

32. Kiselyov A., Balakin K.V., Tkachenko S.E. VEGF/VEGFR signalling as a target for inhibiting angiogenesis. Expert Opinion on Investigational Drugs. 2007; 16(1): 83-107.

33. Dorogov M.V., Ivanovsky S.A., Khakhina M.Y., Kravchenko D.V., Tkachenko S.E., Ivachtchenko A.V. Synthesis of 7-sulfamoyl-substituted 2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepines. Synthetic Communications. 2006; 36(23): 3525-3535

34. Savchuk N.P., Tkachenko S.E., Balakin K.V. Design of pGPCR-targeted Libraries. In Rognan D., ed. Ligand Design for G Protein-coupled Receptors. Methods and Principles in Medicinal Chemistry (Volume 30). Weinheim: Wiley VCH. 2006, pp. 137-164.

35. Filimonov S.I., Korsakov M.K., Kravchenko D.V., Dorogov M.V., Tkachenko S.E., Ivachtchenko A.V. Convenient synthesis of novel 5-substituted 3-methylisoxazole-4-sulfonamides. Journal of Heterocyclic Chemistry. 2006; 43(3): 663-671.

36. Okun I., Malarchuk S., Dubrovskaya E., Khvat A., Tkachenko S., Kysil V., Kravchenko D., Ivachtchenko A. Screening for Caspase-3 Inhibitors: Effect of a Reducing Agent on Identified Hit Chemotypes. Journal of Biomolecular Screening. 2006; 11(6): 694-703.

37. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. New variant of the Pfizinger reaction. Synthesis and chemical transformations of substituted 2-aminomethyl-quinoline-3,4-dicarboxylic acids. Heterocyclic Communications. 2006; 12(1): 15-18.

38. Trifilenkov A.S., Kobak V.V., Kuzovkova J.A., Ilyin A.P., Khvat A.V., Tkachenko S.E., Ivachtchenko A.V. Liquid-Phase Parallel Synthesis of Combinatorial Libraries of Substituted 6-Carbamoyl-3,4-dihydro-2H-benzo[1,4]thiazines. Journal of Combinatorial Chemistry. 2006; 8(4): 469-479.

39. Kiselyov A., Balakin K.V., Tkachenko S.E., Savchuk N.P. Recent Progress in Development of Non-ATP Competitive Small-Molecule Inhibitors of Protein Kinases. Mini Reviews in Medicinal Chemistry. 2006; 6(6): 711-717.

40. Shevyakov S.V., Davydova O.I., Pershin D.G., Krasavin M., Kravchenko D.V., Kiselyov A., Tkachenko S.E., Ivachtchenko A.V. Natural products as templates for bioactive compound libraries: synthesis of biaryl derivatives of (+/-)-vasicine. Natural Product Research. 2006; 20(8): 735-741.

41. Ilyn A.P., Loseva M.V., Vvedensky V.Y., Putsykina E.B., Tkachenko S.E., Kravchenko D.V., Khvat A.V., Krasavin M.Y., Ivachtchenko A.V. One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines. Journal of Organic Chemistry. 2006; 71(7): 2811-2819.

42. Bologa C.G., Revankar C.M., Young S.M., Edwards B.S., Arterburn J.B., Kiselyov A.S., Parker M.A., Tkachenko S.E., Savchuck N.P., Sklar L.A., Oprea T.I., Prossnitz E.R. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature Chemical Biology. 2006; 2(4): 207-212.

43. Kravchenko D.V., Kuzovkova J.A., Kysil V.M. Tkachenko S.E., Malarchuk S., Okun I.M., Ivachtchenko A.V. Pyrrolo[3,4-c]Quinoline-1,3-Diones as Potent Caspase-3 Inhibitors: Synthesis and SAR of 8-Sulfamoyl-1,3-Dioxo-2,3-Dihydro-1H-Pyrrolo[3,4- c]Quinolines. Letters in Drug Design & Discovery. 2006; 3(1): 61-70.

44. Okun I., Malarchuk S., Dubrovskaya E., Khvat A., Tkachenko S., Kysil V., Ilyin A., Kravchenko D., Prossnitz E.R., Sklar L., Ivachtchenko A. Screening for Caspase-3 Inhibitors: A New Class of Potent Small-Molecule Inhibitors of Caspase-3. Journal of Biomolecular Screening. 2006; 11(3): 277-85.

45. Kravchenko D.V., Kysil V.M., Ilyn A.P., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. Synthesis and Chemical Transformations of 6-(Morpholine-4-sulfonyl)-quinoline-2,3,4-tricarboxylic Acid. Synthetic Communications. 2006; 36: 911-917.

46. Ilyin A.P., Kobak V.V., Dmitrieva I.G., Peregudova Y.N., Kustova V.A., Mishunina Y.S., Ivachtchenko A.V. Synthesis of 7,8-Dihydrothieno-[3′,2′:4,5]pyrrolo[1,2-a]pyrazin-5(6H)-ones Using a Modification of Four-Component Ugi Reaction. Synthetic Communications. 2006; 36: 903-910.

47. Ilyin A.P., Parchinski V.Z., Peregudova J.N., Tri.lenkov A.S., Poutsykina E.B., Tkachenko S.E., Kravchenko D.V. Ivachtchenko A.V. One-step assembly of carbamoyl substituted annulated 1,4-oxazepines. Tetrahedron Letters. 2006; 47(15): 2649-2653.

48. Ekins S, Balakin KV, Savchuk N, Ivanenkov Y. Insights for human ether-a-go-go-related gene potassium channel inhibition using recursive partitioning and Kohonen and Sammon mapping techniques. Journal of Medicinal Chemistry. 2006; 49(17): 5059-71.

49. Balakin KV, Kozintsev AV, Kiselyov AS, Savchuk NP. Rational design approaches to chemical libraries for hit identification. Current Drug Discovery Technologies. 2006; 3(1): 49-65.

50. Balakin KV, Savchuk NP, Tetko IV. In silico approaches to prediction of aqueous and DMSO solubility of drug-like compounds: trends, problems and solutions. Current Medicinal Chemistry. 2006; 13(2): 223-41.

51. Shevyakov SV, Davydova OI, Kiselyov AS, Kravchenko DV, Ivachtchenko AV, Krasavin M. Natural products as templates for bioactive compound libraries: part 2. Novel modifications of vasicine (peganine) core via efficient and regioselective generation of 3-lithiodeoxyvasicine and its stereoselective addition to aliphatic ketones section sign. Natural Product Research. 2006; 20(9): 871-81.

52. Ilyin A, Kysil V, Krasavin M, Kurashvili I, Ivachtchenko AV. Complexity-enhancing acid-promoted rearrangement of tricyclic products of tandem Ugi 4CC/intramolecular Diels-Alder reaction. Journal of Organic Chemistry. 2006; 71(25): 9544-7.

53. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. Synthesis and caspase-3 inhibitory activity of 8-sulfonyl-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines. Farmaco. 2005; 60(10): 804-9.

54. Ilyin A.P., Kobak V.V., Dmitrieva I.G., Peregudova Y.N., Kustova V.A., Mishunina Y.S., Tkachenko S.E., Ivachtchenko A.V. Synthesis of annelated azaheterocycles containing a 5-carbamoylpyrazin-3-one fragment by a modification of the four-component Ugi reaction. European Journal of Organic Chemistry. 2005; (21): 4670-4679.

55. Kravchenko D.V., Kysil V.M., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones. European Journal of Medicinal Chemistry. 2005; 40(12): 1377-1383.

56. Vvedensky V.Y., Ivanov Y.V., Kysil V., Williams C., Tkachenko S., Kiselyov A., Khvat A.V., Ivachtchenko A.V. Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones Tetrahedron Letters. 2005; 46: 3953-3956.

57. Kravchenko D.V., Kysil V.M., Ilyn A.P., Tkachenko S.E., Maliarchouk S., Okun I.M., Ivachtchenko A.V. 1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2005; 15(7): 1841-1845.

58. Kravchenko D.V., Kuzovkova Y.A., Kysil V.M., Tkachenko S.E., Maliarchouk S., Okun I.M., Balakin K.V., Ivachtchenko A.V. Synthesis and Structure-Activity Relationship of 4-Substituted 2-(2-Acetyloxyethyl)-8-(morpholine- 4-sulfonyl)pyrrolo[3,4-c]quinoline- 1,3-diones as Potent Caspase-3 Inhibitors Journal of Medicinal Chemistry. 2005; 48(11): 3680-3683.

59. Ilyin A.P., Kuzovkova J.A., Potapov V.V., Shkirando A.M., Kovrigin D.I., Tkachenko S.E., Ivachtchenko A.V. An efficient synthesis of novel heterocycle-fused derivatives of 1-oxo-1,2,3,4-tetrahydropyrazine using Ugi condensation. Tetrahedron Letters. 2005; 46(5): 881-884.

60. Balakin KV, Ivanenkov YA, Savchuk NP, Ivashchenko AA, Ekins S. Comprehensive computational assessment of ADME properties using mapping techniques. Current Drug Discovery Technologies. 2005; 2(2): 99-113.

61. Zhuravel’ IO, Kovalenko SM, Ivachtchenko AV, Balakin KV, Kazmirchuk VV. Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides. Bioorganic & Medicinal Chemistry Letters. 2005; 15(24):5483-7.

62. Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI. Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Molecular Pharmacology. 2005; 68(5): 1301-10.

63. Savchuk N.P., Tkachenko S.E., Balakin K.V. Rational design of GPCR-specific combinatorial libraries based on the concept of privileged substructures. In T Oprea, ed. Cheminformatics in Drug Discovery. Weinheim: Wiley VCH. 2005, pp. 287-313.

64. Ilyn AP, Trifilenkov AS, Tsirulnikov SA, Kurashvily ID, Ivachtchenko AV. Synthesis of 4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-6-carboxamides using a modification of Ugi condensation. Journal of Combinatorial Chemistry. 2005; 7(6):806-8.

65. Ilyin AP, Trifilenkov AS, Kurashvili ID, Krasavin M, Ivachtchenko AV. One-step construction of peptidomimetic 5-carbamoyl-4-sulfonyl-2-piperazinones. Journal of Combinatorial Chemistry. 2005; 7(3): 360-3.

66. Ivachtchenko AV, Kobak VV, Ilyn AP, Khvat AV, Kysil VM, Williams CT, Kuzovkova JA, Kravchenko DV. Parallel liquid-phase synthesis of N-substituted 6-aminosulfonyl-2-oxo-1,2-dihydroquinoline-4-carboxamide and 6-aminosulfonylquinoline-4-carboxamide derivatives. Journal of Combinatorial Chemistry. 2005; 7(2): 227-35.

67. Ilyn AP, Trifilenkov AS, Kuzovkova JA, Kutepov SA, Nikitin AV, Ivachtchenko AV. New four-component Ugi-type reaction. Synthesis of heterocyclic structures containing a pyrrolo[1,2-a][1,4]diazepine fragment. Journal of Organic Chemistry. 2005; 70(4): 1478-81.

68. Ivachtchenko A.V., Tkachenko S.E., Khvat A.V., Sandulenko Y.V., Vvedensky V.Y. A parallel solution-phase synthesis of substituted 3,7-diazabicyclo[3.3.1]nonanes. Journal of Combinatorial Chemistry. 2004; 6(5): 828-834.

69. Ivachtchenko A.V., Khvat A.V., Tkachenko S.E., Sandulenko Y.B., Vvedensky V.Y. Access to novel substituted diazaadamantanes via seminatural tetrahydrocytisine. Tetrahedron Letters. 2004; 45(36): 6733-6736.

70. Savchuk N.P., Balakin K.V., Tkachenko S.E. Exploring the chemogenomic knowledge space with annotated chemical libraries. Current Opinion in Chemical Biology. 2004; 8(4): 412-417.

71. Balakin A., Tkachenko S., .Okun I., Scorenko A., Ivanenkov Y., Savchuk N., Ivashchenko A., Nikolsky Y. Bioisosteric Morphing in Primary Hit Optimization. Chimica OGGI/Chemistry Today. 2004; 22(1/2): 15-18.

72. Tkachenko S., Okun I., Balakin K., Petersen C., Ivanenkov Y., Savchuk N., Ivashchenko A. Efficient Optimization Strategy for Marginal Hits Active Against abl Tyrosine Kinases. Current Drug Discovery Technologies. 2004; 1(3): 201-210.

73. Balakin KV, Ekins S, Bugrim A, Ivanenkov YA, Korolev D, Nikolsky YV, Ivashchenko AA, Savchuk NP, Nikolskaya T. Quantitative structure-metabolism relationship modeling of metabolic N-dealkylation reaction rates. Drug Metabolism and Disposition. 2004; 32(10): 1111-20.

74. Balakin KV, Ekins S, Bugrim A, Ivanenkov YA, Korolev D, Nikolsky YV, Skorenko AV, Ivashchenko AA, Savchuk NP, Nikolskaya T. Kohonen maps for prediction of binding to human cytochrome P450 3A4. Drug Metabolism and Disposition. 2004; 32(10): 1183-9.

75. Balakin KV, Ivanenkov YA, Skorenko AV, Nikolsky YV, Savchuk NP, Ivashchenko AA. In silico estimation of DMSO solubility of organic compounds for bioscreening. Journal of Biomolecular Screening. 2004; 9(1): 22-31.

76. Balakin K.V., Lang S.A., Skorenko A.V., Tkachenko S.E., Ivashchenko A.A., Savchuk N.P. Structure-based versus property-based approaches in the design of G-protein-coupled receptor-targeted libraries. Journal of Chemical Information and Computer Science. 2003; 43(5): 1553-1562.

77. Ivanenkov Ya., Balakin K., Skorenko A., Tkachenko S., Savchuk N., Ivashchenko A.A., Nikolsky Yu. Application of advanced machine learning algorithm for profiling specific GPCR-active compounds. Chimica OGGI/Chemistry Today. 2003; 21(6): 72-75.

78. Balakin AV, Lang SA, Tkachenko SE, Ivashchenko A.A., Savchuk N.P. Pre-synthetic Combinatorial Design: Trends Toward Intelligent Computational Technologies. Chimica OGGI/Chemistry Today. 2003; 21(3/4): 63-66.

79. Zernov VV, Balakin KV, Ivaschenko AA, Savchuk NP, Pletnev IV. Drug discovery using support vector machines. The case studies of drug-likeness, agrochemical-likeness, and enzyme inhibition predictions. Journal of Chemical Information and Computer Science. 2003; 43(6): 2048-56.

80. Korolev D, Balakin KV, Nikolsky Y, Kirillov E, Ivanenkov YA, Savchuk NP, Ivashchenko AA, Nikolskaya T. Modeling of human cytochrome p450-mediated drug metabolism using unsupervised machine learning approach. Journal of Medicinal Chemistry. 2003; 46(17): 3631-43.

81. Trepalin SV, Skorenko AV, Balakin KV, Nasonov AF, Lang SA, Ivashchenko AA, Savchuk NP. Advanced exact structure searching in large databases of chemical compounds. Journal of Chemical Information and Computer Science. 2003; 43(3): 852-60.

82. Ivachtchenko AV, Kovalenko SM, Drushlyak OG. Synthesis of substituted 4-oxo-2-thioxo-1,2,3,4-tetrahydroquinazolines and 4-oxo-3,4-dihydroquinazoline-2-thioles. Journal of Combinatorial Chemistry. 2003; 5(6): 775-88.

83. Balakin AV, Tkachenko SE, Lang SA, Okun IM, Ivashchenko AA, Savchuk NP. Property-Based Design of GPCR-Targeted Library. Journal of Chemical Information and Computer Science. 2002; 42(6): 1332-1346.

84. Ivachtchenko AV, Il’yin AP, Kobak VV, Zolotarev DA, Boksha LV, Trifilenkov AS, Ugoleva DM. New scaffolds for combinatorial synthesis. 1. 5-sulfamoylisatins and their reactions with 1,2-diamines. Journal of Combinatorial Chemistry. 2002; 4(5): 419-28.